Two New Isomeric Andrographolides with Anti‐Inflammatory and Cytotoxic Activity

Abstract Two novel epimerized andrographolides, 8,17‐dihydro‐7,8‐dehydroandrographolide and 10 β ‐8,17‐dihydro‐7,8‐dehydroandrographolide, were isolated from andrographolide sulfonates. Their structures were elucidated by detailed NMR analysis, single‐crystal X‐ray diffraction and quantum chemical ECD calculations. In addition, these compounds exhibited suppression of NO production in LPS‐stimulated RAW264.7 cells over the range of 1.564 to 25.000 μg/mL.