Invasive mechanical ventilation in different times for AECOPD combined with severe respiratory failure

Objective To observe the effect of invasive mechanical ventilation in different times for chronic obstructive pulmonary disease (AECOPD) combined with severe respiratory failure. Methods 136 patients with AECOPD combining severe respiratory failure treated at our hospital from August, 2014 to September, 2017 were selected, and were divided into an observation group and a control group by random number table method, 68 cases for each group. The observation group were treated with invasive mechanical ventilation within 6 h and the control group after 6 h. The changes of blood gas indexes, clinical indicators, and complications were compared. Results The PaCO2 was lower and the PaO2 and PaO2/FiO2 were higher after than before the treatment in both groups, and they were in the observation group than in the control group after the treatment, with statistical differences (all P < 0.05). The total invasive mechanical ventilation time, total mechanical ventilation time, and the ICU stay were (57.67±14.14) h, (152.57±27.74) h, and (6.71±1.36) d in the observation group, which were shorter than those in the control group, with statistical differences (all P < 0.05). The incidence ventilator associated pneumonia was lower in the observation group than in the control group (10.29% vs. 25.00%), with a statistical difference (P < 0.05). Conclusions Patients with AECOPD complicating severe respiratory failure and clear invasive mechanical ventilation related indications taking invasive mechanical ventilation therapy as early as possible can better improve their blood gas indexes and reduce mechanical ventilation time and the incidence of related complications, and is safe. Key words: Chronic obstructive pulmonary disease; Acute exacerbation; Severe respiratory failure; Invasive mechanical ventilation.