自愈水凝胶
羧甲基纤维素
肿胀 的
生物相容性
材料科学
聚(N-异丙基丙烯酰胺)
化学工程
化学
盐酸四环素
高分子化学
复合数
聚合物
复合材料
钠
四环素
共聚物
冶金
抗生素
工程类
生物化学
作者
Su Chen,Jia Liu,Zhuoran Yang,Lei Jiang,Xiufeng Liu,Wei Shao
标识
DOI:10.1016/j.ijbiomac.2020.06.094
摘要
Carboxymethyl cellulose (CMC)/pPoly-N-isopropylacrylamide (PNIPAM) hydrogels were prepared using nanoclay as physical cross-linker by UV irradiation. PNIPAM/CMC hydrogels exhibit 3D network structures with high porosity. PNIPAM/CMC hydrogels exhibit not only high water absorption capacity, but also temperature, pH and salt mutiple-responsive swelling performance. Besides, they exhibit reversible swelling behavior in alternate de-ionized water and NaCl solution. Moreover, the fabricated PNIPAM/CMC hydrogels display great compression mechanical property. Then, tetracycline hydrochloride (TCH) was loaded into the PNIPAM/CMC hydrogels to endow their antibacterial ability. TCH loaded PNIPAM/CMC hydrogels exhibit excellent antibacterial activity against E. coli and B. subtilis and good biocompatibility. Thus, the PNIPAM/CMC composite hydrogels with triple stimuli-responsive swelling performances reported herein have great potentials in many biomedical applications.
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