Clinical value of pepsinogen levels detection in early diagnosis of gastric cancer

Objective To study the correlation between the contents of serum pepsinogen I,II and atrophic gastritis and gastric caner,and investigate the clinical value of serum pepsinogen level in early diagnosis of atrophic gastritis and gastric cancer.Methods Chemiluminescence assay was used to detect the levels of PGI,II in patients with chronic atrophic gastritis,chronic superficial gastritis and those with gastric cancer,and the results and PGI /II ratio were compared among the three groups. Results Compared with the chronic superficial gastritis group,serum PG I values and PGI /II ratio in both atrophic gastritis and gastric cancer groups decreased significantly( P 0. 05). While there was no significant difference of serum PG I,II levels and PGI /II ratio between chronic atrophic gastritis group and gastric cancer group( P 0. 05). Compared with chronic superficial gastritis group,there was larger probability of PG I less than 65 ng /ml and PGI /II ratio 3 in chronic atrophic gastritis group and gastric cancer group( P 0. 05). Conclusion The decrease of serum PGI,PGII levels and the PGI /II ratio is valuable for the early diagnosis of chronic atrophic gastritis and gastric cancer.