Toxicokinetic study on intravenous infused LHPLC(hydroxycamptothecin liposome)by beagle dog model

Objective:To study the toxicokinetics of LHCPT in Beagle dogs by intravenous infusion,and discuss the accumulative effects of LHCPT in blood.Methods:HPLC with fluorescence detection was used to analyze drug concentration in whole blood.Results:Cmax and AUC were increased in a dose-dependent manner both after 1st day and 30th day;and there was no statistical significance in t1/2 of different doses(P 0.05).Compared with single administration with repetition,there were no obvious changes of AUC,Cmax and t1 /2 of the same dose(P 0.05).Conclusion:LHCPT has no significantly accumulative effects after successive intravenous administration.