Objective To observe the long-term effectiveness and safety of domestic clopidogrel (Talcom) on patients after percutaneous coronary intervention (PCI).Methods A total of 257 patients were randomly divided into two groups after PCI,including domestic clopidogrel group (n=129) and imported clopidogrel (Plavix) group (n=128),300 mg of clopidogrel were given 6 hours prior to PCI respectively followed by 75 mg daily,Major adverse cardiac events (MACE) and adverse effects were observed in 12 months after PCI. Results There was no statistic significance in MACE and adverse effect in 12 months after PCI. Conclusion Domestic clopidogrel may be effective and safe for patients after PCI,which is economic and worthy of further clinical application.