Biological characteristics of bone in SAMP6 as a murine model for senile osteoporosis

Osteoporosis is a progressive bone disease with a high incidence.The pathogenesis of osteoporosis is still unknown,so it is necessary to study the pathogenic mechanisms of osteoporosis extensively and deeply.Many animal models for osteoporosis only concentrate on one facet of the disease and can not be used widely.Compared with other models for osteoporosis,the biological characteristics of bone in senescence-accelerated mouse prone 6(SAMP6) are analogous to changes occurred in aging human skeleton,including low peak bone mass,low bone mineral density and ultrastructural changes of bone,so SAMP6 is a predominant and functionally relevant model in understanding the pathogenesis and developing effective therapeutics of senile osteoporosis.