Objective: To study the effect of boiling processes on the quality of Paeony compound decoction and to make the best boiling process.Methods: Automatic decoction machine and traditional decoction process were used to boil the prescription herbal medicines and the same factors were set.HPLC was used to determine the content of paeoniflorin in the decoction.Results: Medicinal materials were soaked for 60min and boiled twice for 30min in the traditional way.The boiled decoction has the highest content of paeoniflorin,0.371mg/ml.Based on the indicator,the decoction had the highest content of paeoniflorin both in the decoction made by the automatic decoction machines and traditional decoction process.Conclusion: By the comparison of the decoction made by the machine and the traditional process,the traditional process is of more efficiency and the decoction is more effective,even if on the same factor in the liquid of per ml,the paeoniflorin content in the decoction made by traditional process is higher than that made by the machine.