Rat Intestinal Absorption of Five Chemical Compositions of Match-pair of Coptis-Evodia

Objective To study the intestinal absorption of different match-pair of Coptis-Evodia,to compare the intestinal absorption rate and absorption coefficient of the five chemical compositions. Methods Single pass perfusion model in rats and HPLC were used to study the concentration and absorption coefficients of the five chemical compositions.The absorption and transport in the small intestine of match-pair of Coptis-Evodia were investigated. Results As the ratio of Coptis increased,the absorption rate of the five chemical components tended to increase,and the berberine,palmatine,evodiamine and rutaecarpine of Coptis-Evodia 6:1 were larger than 1∶1 and 2∶1,the difference was significant(P 0.01);the Ka Kapp of the five chemical components tended to increase,and the berberine,palmatine,Jatrorrhizine and rutaecarpine of Coptis-Evodia 6∶1 were larger than 1∶1and 2∶1,the difference was significant(P 0.01). Conclusion Increasing the compatibility of Coptis proportion is benefit to the chemical compositions of Coptis or Evodia.The absorption position of match-pair of Coptis-Evodia may be in the small intestine.