Clinical features of hand-foot-mouth disease caused by enterovirus 71

Objectives To understand the difference of clinical features of hand-foot-mouth disease(HFMD) caused by enterovirus 71 and other enterovirus types.Methods A total of 106 children with HFMD were included and divided into three groups according to etiology: group 1(enterovirus 71 infection,n = 63),group 2(Coxsackievirus A16 infection,n = 16) and group 3(other enterovirus types infection,n = 27).The information of fever,rash and clinical manifestations of nervous system,respiratory and circulatory systems,and the laboratory data were summarized and analyzed among the three groups.Results The patients in group 1 had higher incidence of central nervous system infection than that of group 2 and group 3.The patients in group 1 had higher peak temperature,longer fever time and more frequent limb tremor and irritation than that in group 2(P 0.05).The patients of CA16 had higher incidence of headache,vomiting,convulsion than that in group 1(P 0.05).Conclusions Patients with EV71 infection had higher peak temperature,longer fever time,higher incidence of central nervous system infection,more frequent limb tremor and irritation than other enterovirus types infection.These characteristics may help pediatricians to identify the type of enterovirus.