Powdery mildew is one of the major diseases of common wheat worldwide.Development and utilization of wheat cultivars with resistance gene is an efficient,economic and environmentally safe strategy to control powdery mildew.The 6VS/6AL translocation line 92R149(highly resistant to powdery mildew with resistance gene Pm21)as female parent,and wheat line Xin 96-74 with large spike,but highly susceptible to powdery mildew as male parent,through hybridization resistant and high-yield gene was restructured.The genetic variation of the main character of parents and hybrid F2,F3 was studied.The results indicated that 92R149 specific resistance to powdery mildewand Xin 96-74 features a large spike can be directly passed to the offspring and variation of hybrid progenies was very rich.Powdery mildewresistant and large spike plant were bred.