The expression of Fas/FasL and p53 in retinoblastoma

Objective To investigate the siginificance of Fas/FasL and p53 expression in retinoblastoma.Methods FasL,Fas and bcl 2 were detected immunohistochemically in 45 cases of retinoblastoma and 12 cases of normal retina.Results The expression of Fas in retinoblastoma and normal retina were very low with no difference( P 0.05).The expression of FasL in retinoblastoma and normal retina were high,but with no significantly difference( P 0.05).p53 was highly expressed in retinoblastoma and low expressed in normal retina,with significant difference( P 0.0002).Conclusion High expression of FasL and low expression of Fas in retinoblastoma and normal retina suggested that they might be associated with immune escape.The high expression of p53 in retinoblastoma was closely associated with the tumor development.\;