Relationship between the expression of MMP-2 and MMP-9 in acute leukemia cells and leukemia infiltration

Objective:To investigate the expression of MMP-2 and MMP-9 in acute leukemia and normal control and explore the relationship among MMP-2、MMP-9 and leukemia pathogenesis and infiltration.Method:The expression of MMP-2 and MMP-9 in bone marrow cells of untreated acute leukemia, relapse stage of acute leukemia, complete remission (CR) stage of acute leukemia and normal control were examined by in situ hybridization.Result:The positive rate of MMP-2 and MMP-9 in untreated, especially with infiltration and relapse stage of acute leukemia are significantly higher than that in CR stage of acute leukemia and normal control, the positive rate of MMP-2 and MMP-9 in untreated acute lymphoblastic leukemia(ALL) and acute nonlymphoblastic leukemia (ANLL) (M_4+M_5)group are significantly higher than that in ANLL (non M_4+M_5 )group.Conclusion:MMP-2 and MMP-9 may play an important role in leukemia pathogenesis and infiltration by enhancing the degradation of ECM.