Impaired Myocardial Mitochondrial Respiration in Humans With Prediabetes: A Footprint of Prediabetic Cardiomyopathy

HomeCirculationVol. 146, No. 15Impaired Myocardial Mitochondrial Respiration in Humans With Prediabetes: A Footprint of Prediabetic Cardiomyopathy No AccessLetterRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessLetterRequest AccessFull TextImpaired Myocardial Mitochondrial Respiration in Humans With Prediabetes: A Footprint of Prediabetic Cardiomyopathy Elric Zweck, MD, Daniel Scheiber, MD, Heinz-Peter Schultheiss, MD, Oliver Kuss, PhD, Malte Kelm, MD, Michael Roden, MD, Ralf Westenfeld, MD and Julia Szendroedi, MD, PhD Elric ZweckElric Zweck https://orcid.org/0000-0001-6739-476X Division of Cardiology, Pulmonology and Vascular Medicine (E.Z., D.S., M.K., R.W.), Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany Institute for Clinical Diabetology (E.Z., D.S., M.R., J.S.), German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich-Heine University, Düsseldorf. Institute for Biometrics and Epidemiology (O.K.), German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich-Heine University, Düsseldorf. Search for more papers by this author , Daniel ScheiberDaniel Scheiber https://orcid.org/0000-0002-6352-2565 Division of Cardiology, Pulmonology and Vascular Medicine (E.Z., D.S., M.K., R.W.), Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany Institute for Clinical Diabetology (E.Z., D.S., M.R., J.S.), German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich-Heine University, Düsseldorf. Institute for Biometrics and Epidemiology (O.K.), German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich-Heine University, Düsseldorf. Search for more papers by this author , Heinz-Peter SchultheissHeinz-Peter Schultheiss Heinrich-Heine University, Düsseldorf, Germany (H-P.S.). Search for more papers by this author , Oliver KussOliver Kuss https://orcid.org/0000-0003-3301-5869 Institute for Biometrics and Epidemiology (O.K.), German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich-Heine University, Düsseldorf. Search for more papers by this author , Malte KelmMalte Kelm https://orcid.org/0000-0003-0060-1052 Division of Cardiology, Pulmonology and Vascular Medicine (E.Z., D.S., M.K., R.W.), Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany Cardiovascular Research Institute Düsseldorf (M.K., M.R.), Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany Search for more papers by this author , Michael RodenMichael Roden Institute for Clinical Diabetology (E.Z., D.S., M.R., J.S.), German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich-Heine University, Düsseldorf. German Center for Diabetes Research, Partner Düsseldorf, München-Neuherberg (E.Z., D.S., M.R., J.S.). Cardiovascular Research Institute Düsseldorf (M.K., M.R.), Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany Division of Endocrinology and Diabetology (M.R.), Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany Search for more papers by this author , Ralf WestenfeldRalf Westenfeld Division of Cardiology, Pulmonology and Vascular Medicine (E.Z., D.S., M.K., R.W.), Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany Search for more papers by this author and Julia SzendroediJulia Szendroedi Correspondence to: Julia Szendroedi, MD, PhD, Department of Endocrinology, Diabetology, Metabolism, and Clinical Chemistry, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany. Email E-mail Address: [email protected] https://orcid.org/0000-0002-7296-7152 Department of Internal Medicine I and Clinical Chemistry, University Hospital Heidelberg, Heidelberg; Institute for Diabetes and Cancer; and Joint Heidelberg-IDC Translational Diabetes Program, Helmholtz Center Munich, München-Neuherberg, Germany (J.S.). Institute for Clinical Diabetology (E.Z., D.S., M.R., J.S.), German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich-Heine University, Düsseldorf. German Center for Diabetes Research, Partner Düsseldorf, München-Neuherberg (E.Z., D.S., M.R., J.S.). Search for more papers by this author Originally published10 Oct 2022https://doi.org/10.1161/CIRCULATIONAHA.122.058995Circulation. 2022;146:1189–1191FootnotesCirculation is available at www.ahajournals.org/journal/circFor Sources of Funding and Disclosures, see page 1191.Correspondence to: Julia Szendroedi, MD, PhD, Department of Endocrinology, Diabetology, Metabolism, and Clinical Chemistry, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany. Email Julia.[email protected]uni-heidelberg.deReferences1. Wu JD, Liang D, Xie Y. Prediabetes and risk of heart failure: the link grows stronger.Cardiovasc Diabetol. 2021; 20:112. doi: 10.1186/s12933-021-01302-wCrossrefMedlineGoogle Scholar2. Nunes S, Soares E, Fernandes J, Viana S, Carvalho E, Pereira FC, Reis F. Early cardiac changes in a rat model of prediabetes: brain natriuretic peptide overexpression seems to be the best marker.Cardiovasc Diabetol. 2013; 12:44. doi: 10.1186/1475-2840-12-44CrossrefMedlineGoogle Scholar3. Zweck E, Scheiber D, Jelenik T, Bonner F, Horn P, Pesta D, Schultheiss HP, Boeken U, Akhyari P, Lichtenberg A, et al. Exposure to type 2 diabetes provokes mitochondrial impairment in apparently healthy human hearts.Diabetes Care. 2021; 44:e82–e84. doi: 10.2337/dc20-2255CrossrefMedlineGoogle Scholar4. Scheiber D, Jelenik T, Zweck E, Horn P, Schultheiss HP, Lassner D, Boeken U, Saeed D, Kelm M, Roden M, et al. High-resolution respirometry in human endomyocardial biopsies shows reduced ventricular oxidative capacity related to heart failure.Exp Mol Med. 2019; 51:116–110. doi: 10.1038/s12276-019-0214-6CrossrefGoogle Scholar5. Tura A, Chemello G, Szendroedi J, Gobl C, Faerch K, Vrbikova J, Pacini G, Ferrannini E, Roden M. Prediction of clamp-derived insulin sensitivity from the oral glucose insulin sensitivity index.Diabetologia. 2018; 61:1135–1141. doi: 10.1007/s00125-018-4568-4CrossrefMedlineGoogle Scholar Previous Back to top Next FiguresReferencesRelatedDetails October 11, 2022Vol 146, Issue 15 Advertisement Article InformationMetrics © 2022 American Heart Association, Inc.https://doi.org/10.1161/CIRCULATIONAHA.122.058995PMID: 36214134 Originally publishedOctober 10, 2022 Keywordscardiomyopathiesprediabetic statemitochondriatransplantsdiabetes mellitus, type 2PDF download Advertisement SubjectsHeart FailureMetabolic SyndromeMetabolismPhysiology