Dissociable Neural Connectome Mapping of Reward and Punishment Responsiveness in Young Adults: Associations with Genetic Variability and Neurotransmitter Profiles

= 655 healthy participants, 442 females). Both RS and PS were mapped separately in the brain, with the functional connectome in the fronto-striatal network encoding reward responsiveness, while the fronto-insular system was particularly engaged in punishment sensitivity. These dissociable functional connectome patterns also exhibited high specificity in differentiating decisions driven by social or monetary reward and punishment motivations. Further imaging transcriptomic analyses revealed that functional connectome variations for RS and PS were associated with topography of specific gene sets enriched in ontological pathways, including synaptic transmission, dopaminergic metabolism, immune response, and stress adaptation. On the neurotransmitter level, the serotonin neuromodulator emerged as a pivotal hub regulating the intrinsic functional connectome patterns of RS and PS, with its modulatory effects dependent on interactions with the dopaminergic, opioid, and GABAergic systems. Overall, these findings indicate dissociable neural connectome mapping of RS and PS and highlight their linkage with transcriptomic profiles, which may inform future investigations on early identification of vulnerability and risk factors for psychopathological conditions.