Laboratory Investigation of Lipid Metabolic Reprogramming in Pulpitis: The Linolenic Acid– FASN – NR4A1 Axis in Modulating Dental Pulp Inflammation

This study reveals a pathological FASN-LA-NR4A1 regulatory axis linking lipid metabolism to inflammatory amplification in pulpitis. Dual targeting of fatty acid synthesis and lipid depletion-through FASN inhibition and LA supplementation-attenuates inflammation via NR4A1-dependent mechanisms. These findings lay the groundwork for metabolic approaches to modulate inflammation in endodontics.