[Multidimensional analysis of cranio-maxillofacial joint-neural interactions and their clinical significance].

The interplay between the skeletal and nervous systems has emerged as a pivotal area in modern medical research. Unlike mesodermal-origin trunk skeletons, craniofacial bones demonstrate distinctive neurobiological properties due to their unique embryonic derivation from ectodermal neural crest cells. This article systematically investigates the interaction mechanisms between craniofacial bones and the nervous system through developmental, anatomical, and functional dimensions. It comprehensively elaborates the translational value of this neuro-skeletal association in advancing precision diagnosis and treatment for various pathologies, including temporomandibular joint osteoarthritis, craniofacial bone trauma, and dentition defect restoration. The findings propose novel strategies spanning molecular regulation to clinical translation, offering innovative perspectives for managing craniofacial disorders.