Asymmetric Construction of C(sp3)–SCF3 Motif by CuH-Catalyzed Hydrofunctionalizations of 1-SCF3-alkenes

Trifluoromethylthio (SCF3)-containing molecules are highly valuable in medicinal chemistry and agrochemistry, and efficient synthetic methods for their preparation thus have been developed. However, an asymmetric construction of C(sp3)–SCF3 motif still remains largely underdeveloped. Herein, we summarize our recent work on the CuH-catalyzed hydrofunctionalizations of 1-SCF3-alkenes, which enable the asymmetric synthesis of nontrivial C(sp3)–SCF3 compounds that are difficult to prepare by other means.