Vitamin D3 exacerbates steatosis while calcipotriol inhibits inflammation in non-alcoholic fatty liver disease in Sod1 knockout mice: a comparative study of two forms of vitamin D

In a lean NAFLD mouse model, vitamin D 3 accentuated hepatic steatosis, while calcipotriol diminished inflammation; the reason may be their selective activation of VDR in hepatocytes and liver macrophages, respectively.