光热治疗
紧身衣
材料科学
光化学
光热效应
纳米技术
化学
荧光
光学
物理
作者
Gibeom Kim,Yoonsoo Hahn,Myunghwan Shin,Jean Bouffard,Jang‐Ho Bae,Youngmi Kim
标识
DOI:10.1002/adhm.202400885
摘要
Abstract The successful implementation of photothermal therapy (PTT) in cancer treatment hinges on the development of highly effective photothermal agents (PTAs). BODIPY dyes, being well known for their high brightness and quantum efficiencies, are the antithesis of PTAs. Nonetheless, a systematic exploration of the photophysics and photothermal characteristics of a series of π‐extended BODIPY dyes with high absorptivity in the near‐infrared (NIR) region has achieved superior photothermal conversion efficiencies (>90%), in both monomeric state and nanoparticles after encapsulation in a biocompatible polyethyleneglycol (DSPE‐PEG 2000 ). Optimal PTA candidates combined strong NIR absorption provided by extended donor‐acceptor conjugation, and an optimization of the electronic and steric effects of meso ‐substituents to maximize photothermal conversion performance. The PTT‐optimized meso ‐CF 3 ‐BODIPY, T CF 3 P En exhibits exceptional efficacy in inducing cancer cell apoptosis and in vivo tumor ablation using low‐power NIR laser irradiation (0.3 W/cm 2 , 808 nm) as well as excellent biological safety, underscoring its potential for advancing light‐induced cancer therapies. This article is protected by copyright. All rights reserved
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