间充质干细胞
细胞生物学
调制(音乐)
骨形态发生蛋白2
干细胞
化学
骨形态发生蛋白
生物
生物化学
体外
基因
物理
声学
作者
Tuan Anh Vuong,Yan Zhang,June Kim,Young-Eun Leem,Jong‐Sun Kang
标识
DOI:10.5483/bmbrep.2023-0203
摘要
Arginine methylation, which is catalyzed by protein arginine methyltransferases (Prmts), is known to play a key role in various biological processes. However, the function of Prmts in osteogenic differentiation of mesenchymal stem cells (MSCs) has not been clearly understood. In the current study, we attempted to elucidate a positive role of Prmt7 in osteogenic differentiation. Prmt7-depleted C3H/10T1/2 cells or bone marrow mesenchymal stem cells (BMSCs) showed the attenuated expression of osteogenic specific genes and Alizarin red staining compared to the wild-type cells. Furthermore, we found that Prmt7 deficiency reduced the activation of bone morphogenetic protein (BMP) signaling cascade, which is essential for the regulation of cell fate commitment and osteogenesis. Taken together, our data indicate that Prmt7 plays important regulatory roles in osteogenic differentiation.
科研通智能强力驱动
Strongly Powered by AbleSci AI