嵌合抗原受体
细胞疗法
T细胞
抗原
细胞
癌症研究
医学
免疫系统
免疫学
化学
生物化学
作者
J Long,Yian Wang,Xianjie Jiang,Junshang Ge,Mei‐Jyh Chen,B. Zheng,Rong Wang,Meifeng Wang,Meiling Xu,Ke Qin,Jie Wang
标识
DOI:10.1002/adhm.202304615
摘要
T cell engineering, particularly via chimeric antigen receptor (CAR) modifications for enhancing tumor specificity, has shown efficacy in treating hematologic malignancies. The extension of CAR-T cell therapy to solid tumors, however, is impeded by several challenges: the absence of tumor-specific antigens, antigen heterogeneity, a complex immunosuppressive tumor microenvironment, and physical barriers to cell infiltration. Additionally, limitations in CAR-T cell manufacturing capacity and the high costs associated with these therapies restrict their widespread application. The integration of nanomaterials into CAR-T cell production and application offers a promising avenue to mitigate these challenges. Utilizing nanomaterials in the production of CAR-T cells could decrease product variability and lower production expenses, positively impacting the targeting and persistence of CAR-T cells in treatment and minimizing adverse effects. This review comprehensively evaluates the use of various nanomaterials in the production of CAR-T cells, genetic modification, and in vivo delivery. It discusses their underlying mechanisms and potential for clinical application, with a focus on improving specificity and safety in CAR-T cell therapy. This article is protected by copyright. All rights reserved.
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