材料科学
纳米复合材料
流变学
粘弹性
生物相容性
蜘蛛丝
挤压
明胶
聚合物
纳米颗粒
纺纱
组织工程
复合材料
丝绸
纳米技术
化学
生物医学工程
医学
生物化学
冶金
作者
Hao‐Cheng Yu,Kuang-Yeu Hsieh,Tomoyasu Hirai,Ming‐Chia Li
标识
DOI:10.1021/acs.biomac.3c00522
摘要
Taking inspiration from spider silk protein spinning, we developed a method to produce tough filaments using extrusion-based 3D bioprinting and salting-out of the protein. To enhance both stiffness and ductility, we have designed a blend of partially crystalline, thermally sensitive natural polymer gelatin and viscoelastic G-polymer networks, mimicking the components of spider silk. Additionally, we have incorporated inorganic nanoparticles as a rheological modifier to fine-tune the 3D printing properties. This self-healing nanocomposite hydrogel exhibits exceptional mechanical properties, biocompatibility, shear thinning behavior, and a well-controlled gelation mechanism for 3D printing.
科研通智能强力驱动
Strongly Powered by AbleSci AI