化学
邻氨基苯甲酸
羟基化
葡萄糖醛酸化
药效团
衍生化
水杨酸
组合化学
有机化学
生物化学
酶
微粒体
高效液相色谱法
作者
Mousmee Sharma,Parteek Prasher
标识
DOI:10.2174/1385272827666230914113509
摘要
Abstract: Fenamic acid-derived NSAIDs contain N-phenyl anthranilic acid as a pharmacophore with pKa ~ 4, which is completely ionized at the physiological pH and is mainly excreted in the urine by hydroxylation or glucuronidation. The acid (-COOH) functionality in fenamic acid provides a template for their fenamate derivatization for the development of analogues based on amidation, esterification, and etherification. Besides the repurposing of fenamates as neuroprotective agents in unmodified form, several of their derivatives have been reported for the management of disease pathogenesis by regulating the responsible pathways. In this review, we discuss the chemical modification of fenamic acid and its medicinal chemistry thereof.
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