环丙烷化
流动化学
化学
试剂
锌
碳化物
流量(数学)
连续流动
分子内力
组合化学
有机化学
催化作用
生化工程
铑
工程类
数学
几何学
作者
José Luis Nova‐Fernández,Gustavo Pascual‐Coca,Silvia Cabrera,Jose Julian Aleman Lara
标识
DOI:10.1002/adsc.202300665
摘要
Abstract Flow chemistry has recently opened new chemistry windows thanks to the safer use of hazardous and sensitive reagents. Furthermore, flow procedures usually outperform their batch counterparts due to improved mass and heat transfer, offering a good opportunity for industrial application. Herein, a rapid Simmons‐Smith cyclopropanation flow process is presented. Taking advantage of the in situ production of the zinc carbenoid species, several olefins bearing aromatic rings of different electronic nature, aliphatic chains or heterocycles were smoothly cyclopropanated with a residence time of just 15 minutes. In addition, industrial applicability of the protocol is assured thanks to a successful 12‐mmol scale experiment, which represents a 3.59 grams per hour production of a selected example, and to the satisfactory synthesis of pharmaceutical drugs.
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