废止
化学
分子内力
催化作用
叶立德
试剂
磺酰
组合化学
药物化学
立体化学
有机化学
烷基
作者
Peng Zhou,Weitao Yang,Wen‐Juan Hao,Bo Jiang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-11-17
卷期号:25 (47): 8495-8500
标识
DOI:10.1021/acs.orglett.3c03479
摘要
A copper(II)/DBU relay catalyzed annulation of α-carbonyl-γ-alkynyl sulfoxonium ylides as a new class of sulfoxonium ylide reagents with sulfonyl hydrazides is reported, enabling intramolecular oxygen migration to produce a series of N-sulfonamido 2H-isoindoles with good yields. The present annulation proceeded readily by combining the Cu(II)-catalyzed 6-endo-dig oxo-cyclization with the DBU-catalyzed isochromene skeletal rearrangement, resulting in the formation of multiple new chemical bonds.
科研通智能强力驱动
Strongly Powered by AbleSci AI