Electrochemical Oxidative Carbon‐atom Multifunctionalization and N‐Cyanation of Imine: Synthesis of (Z)‐N′‐Cyano‐N‐carbamimidothioate

Abstract Cyanoimines (C=N−CN) are eliciting increased attention because of their extensive presence in medicine and biologically active molecules. This study demonstrated the use of the electrochemical oxidative carbon‐atom multifunctionalization and N ‐cyanation of imine to synthesize ( Z )‐ N ′‐cyano‐ N ‐carbamimidothioate. This multicomponent reaction showed good step economy, thereby providing a tool to construct various cyanoimines. Moreover, good functional‐group tolerance and large‐scale synthesis were achieved under metal‐free and external‐oxidant‐free conditions, indicating the potential applicability of this methodology. magnified image