美罗华
微核
类风湿性关节炎
碎屑成因
淋巴瘤
医学
CD20
关节炎
免疫学
微核试验
抗体
免疫系统
癌症研究
内科学
毒性
作者
Sabry M. Attia,Mohammed A. Al-Hamamah,Moureq R. Alotaibi,Abdullah F. Alasmari,Mohamed S.M. Attia,Sheikh F. Ahmad,Mohamed Mahmoud,Ahmed Nadeem,Mushtaq Ahmad Ansari,Saleh A. Bakheet
标识
DOI:10.1016/j.mrgentox.2023.503635
摘要
Rheumatoid arthritis (RA), an autoimmune disorder in which the immune system attacks healthy cells, is associated with elevated risk of lymphoma. Rituximab, a treatment for non-Hodgkin's lymphoma, has been approved as a treatment for RA. We studied the effects of rituximab on chromosomal stability in collagen-induced arthritis DBA/1J animal models. Micronucleus levels were increased in the mouse models, mainly due to chromosome loss, as detected by fluorescence in situ hybridization; rituximab-treated arthritic mice had significantly less micronucleus formation. Serum 8-hydroxydeoxyguanosine, a DNA oxidative stress marker, was increased in the mice models but reduced following rituximab administration.
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