Solid lipid nanoparticles of lauric Acid: A prospective drug carrier for oral drug delivery

固体脂质纳米粒 月桂酸 化学 并行传输 Zeta电位 毒品携带者 药物输送 泊洛沙姆 色谱法 脂肪酸 纳米颗粒 生物化学 磁导率 材料科学 纳米技术 有机化学 聚合物 共聚物
作者
C.S. Dhanya,Willi Paul,M.R. Rekha,Jenny Roy
出处
期刊:Journal of Molecular Liquids [Elsevier BV]
卷期号:380: 121738-121738 被引量:3
标识
DOI:10.1016/j.molliq.2023.121738
摘要

Lauric acid, a naturally occurring medium-chain saturated fatty acid, is known to exhibit high intestinal absorption and a higher propensity for lymphatic absorption. To tap these advantages for nanoparticle-mediated sustained drug delivery, solid lipid nanoparticles of lauric acid (LA-SLN) were prepared by the hot homogenization method. A fluorescent lipophilic dye, Rhodamine B (RhB), was incorporated into the LA-SLN (R-LA-SLN) as a model drug. The particle size and the zeta potential of the LA-SLN were 21.42 ± 1.83 nm and −3.17 ± 0.21 mV, respectively, in phosphate buffer. The encapsulation efficiency and drug loading capacity achieved by R-LA-SLN were about 80.31 ± 0.18 % and 1.02 ± 0.02 %, respectively. In vitro studies revealed a biphasic drug release pattern and were found to follow a Fickian diffusion model. It was found that 52 % RhB was released from R-LA-SLN in the initial 4 h and 71 % in 10 h. The cytotoxic response of LA-SLN was tested on colorectal cancer cells and it elicited only mild cytotoxicity. The cellular uptake studies conducted with colon cancer cells revealed that R-LA-SLN uptake by the cells was twice that of free RhB. The confocal microscopy and Raman mapping showed localization of R-LA-SLN in the cytoplasm on cellular uptake. R-LA-SLN was found to mediate tight junction opening and increased the paracellular permeability by 6 times over free RhB. Mucoadhesion of LA-SLN to the rat intestinal colon mucosa was 1.7 times higher than that of chitosan control, indicating the probability of a longer-duration drug release in the colon.
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