Nanostructured and molecular ROS generators for Photo- and Sonodynamic therapy

Sonodynamic therapy can dramatically enhance the efficiency of non-invasive tumor treatment due to multiple mechanisms initiating cell apoptosis or necrosis under ultrasound action combined with molecular and nanostructured sonosensitizers. Recently, we have demonstrated for the first time the sonodynamic effect of low-intensity 20 kHz ultrasound combined with chlorin e6 on melanoma cells.