光热治疗
聚丙烯酰胺
伤口愈合
体内
金黄色葡萄球菌
材料科学
涂层
自愈水凝胶
生物医学工程
化学
纳米技术
医学
外科
高分子化学
细菌
遗传学
生物技术
生物
作者
Yaoyao Li,Ke Yang,Zefeng Wang,Jiayu Xiao,Zifeng Tang,Huan Li,Wenhua Yi,Zhaoli Li,Yuze Luo,Junqin Li,Xueyao Zhou,Le Deng,Dinggeng He
出处
期刊:ACS applied bio materials
[American Chemical Society]
日期:2022-08-22
卷期号:5 (9): 4541-4553
被引量:6
标识
DOI:10.1021/acsabm.2c00602
摘要
Pathogenic bacterial infections of skin wounds have caused a significant threat to clinical treatment and human life safety. Here, we develop a bactericidal hydrogel dressing consisting of a polyacrylamide (PAM) hydrogel framework with in situ surface-deposition of iron-dopped polydopamine (FePDA). The prepared hydrogel dressing (FePDA–PAM) has a compact surface, good tensile strength, and excellent elastic recovery ability. The introduction of Fe3+ ions improve the photothermal therapy (PTT) efficiency of the PDA and endow the hydrogel dressing with chemodynamic therapy (CDT) properties. In vitro experiments show that the antibacterial effect of FePDA–PAM hydrogel on Staphylococcus aureus reach nearly 100% under the combined action of H2O2 and 808 nm near-infrared (NIR) laser, indicating an excellent combined antibacterial property of PTT and CDT. Furthermore, the FePDA–PAM + H2O2 + NIR treatment group in the in vivo antibacterial experiments displays lowest relative wound area and optimal wound healing within 5 days of treatment, thereby indicating the intensive skin wound disinfection. To summarize, the FePDA–PAM hydrogel has simple preparation and good biosafety. It may serve as a potential wound dressing for the combined PTT/CDT dual-mode antibacterial therapy.
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