Perioral Rejuvenation: Evaluation of Safety and Efficacy of High Molecular Weight Hyaluronic Acid and Amino Acid Treatment

BACKGROUND: The lips and perioral area play a crucial role in facial aesthetics. Signs of aging, such as wrinkles, decreased muscle tone, and thinning skin, frequently appear first in this anatomical area and, subsequently, in other areas. This may explain why the lips and perioral area are frequently requested focus areas for aesthetic treatments that retain the client’s natural features. AIMS: To assess the safety and efficacy of the rejuvenation of the perioral area with an injectable product containing high-molecular-weight (HMW) native hyaluronic acid (HA) and a cluster of amino acids (AAs). PATIENTS/METHODS: In this open-label observational study, 37 female patients underwent 3 monthly sessions of intradermal injections with HMW HA gel with a cluster of AAs. Follow-up investigations were performed after 30, 60, and 180 days. Outcomes were evaluated subjectively using a patient questionnaire, the Global Aesthetic Improvement Scale (GAIS) questionnaire, and objectively using a 3D photosystem. RESULTS: All patients completed the study. The subjective evaluations made by patients and by the investigator during follow up and at the end of the study were positive, and all patients showed improvement in the perioral area. The objective evaluation showed a statistically significant improvement in pores condition and wrinkles. CONCLUSIONS: The protocol for rejuvenation of the perioral area with injections of HMW HA gel and AA is safe and effective. J Drugs Dermatol. 2022;21(9):968-973.doi:10.36849/JDD.6875.