化学
烯烃
激进的
试剂
催化作用
功能群
光催化
肟
组合化学
有机化学
光化学
聚合物
作者
Yu-Shi Jiang,Fu Liu,Miao-Sha Huang,Xue-Ling Luo,Peng-Ju Xia
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-10-20
卷期号:24 (43): 8019-8024
被引量:14
标识
DOI:10.1021/acs.orglett.2c03233
摘要
The modular cyanoalkylamination of alkenes using bench-stable and easy-to-handle α-imino-oxy acid oxime esters as difunctional reagents creates new synthetic avenues. A metal-free photosensitization protocol for the installation of both amino and cyanoalkyl functionalities onto alkene feedstocks in a single step via two differently reactive nitrogen-centered radicals was developed via energy-transfer catalysis. Excellent functional group tolerance and mild reaction conditions also render this protocol suitable for the cyanoalkylamination of pharmaceutically relevant molecule-derived alkenes.
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