化学
筑地反应
路易斯酸
双功能
烷基化
对映选择合成
催化作用
反应性(心理学)
烯丙基重排
药物化学
化学选择性
有机化学
组合化学
医学
病理
替代医学
作者
Fei-Ruo Zhang,Fanshu Cao,Kui Liu,Yiping He,Gen Luo,Zhishi Ye
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-11-20
卷期号:24 (47): 8603-8608
被引量:6
标识
DOI:10.1021/acs.orglett.2c03207
摘要
A chiral Lewis base catalyzed enantioselective N-allylic alkylation of 2-hydroxypyridines and MBH carbonates is documented, affording a convenient access to N-alkylated 2-pyridones with up to 99% ee and 99% yield. Experimental and computational studies have revealed that the strong hydrogen bond interaction between the chiral Lewis base catalyst and 2-hydroxypyridines plays a crucial role in this reaction for the reactivity, chemoselectivity, and enantioselectivity.
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