自愈水凝胶
纳米技术
自组装
堆积
构造(python库)
材料科学
计算机科学
化学
有机化学
高分子化学
程序设计语言
作者
Yu Liu,Xuemin Chen,Shuhua Yin,Xiaoxi Chang,Chenyan Lv,Jiachen Zang,Xiaojing Leng,Tuo Zhang,Guanghua Zhao
出处
期刊:ACS Nano
[American Chemical Society]
日期:2022-10-31
卷期号:16 (11): 19472-19481
被引量:4
标识
DOI:10.1021/acsnano.2c09391
摘要
Engineering proteins to construct self-assemblies is of crucial significance not only for understanding the sophisticated living systems but also for fabricating advanced materials with unexplored functions. However, due to the inherent chemical heterogeneity and structural complexity of the protein surface, designing complex protein assemblies in an anisotropic fashion remains challenging. Here, we describe a self-assembly approach to fabricating protein origami with a networklike structure by designing dual noncovalent interactions on the different positions of a single protein building block. With dimeric proteins as building blocks, 1D protein filaments were constructed by the designed metal coordination at key protein interfaces. Subsequently, the network superstructures were created by the cross-linking of the 1D protein filaments at branch point linkages through the second designed π-π stacking interactions. Notably, upon increasing the protein concentration, the formed protein networks convert into hydrogels with reversible, injectable, and self-healing properties, which have the ability to promote bone regeneration. This strategy could be used to fabricate other protein-based materials with unexplored functions.
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