Antibacterial drugs and cyclodextrin inclusion complexes: a patent review

ABSTRACTIntroduction Bacterial antibiotic resistance occurs when bacteria mutate and escape the effect of antibiotics, which makes the antibiotics no longer effective in treating infections. New solutions for bacterial infections are a persistent need including the identification of drugs with better pharmacological profiles, more potent, and safer. Cyclodextrins inclusion complexes have been able to improve the physicochemical and pharmacological properties of the formulation molecules, resulting in new alternatives with better efficacy.Areas covered The patents analyzed in the review used treatments based on antibiotics already on the market, natural products, and synthesized molecules composed of the formulation with cyclodextrins. The combination between cyclodextrin and nanostructures also were presented in the patents review process. Moreover, inclusion complexes have been an alternative in developing treatment mainly in China by the pharmaceutical industries in several countries such as Germany, Hungary, the United States of America, Japan and China.Expert opinion This review is broad and complete since it considers the first patent involving cyclodextrins and antibacterial drugs. Therefore, the various inclusion complexes and antibacterial drugs alternatives presented in this review offer therapeutic options to fight bacterial infections. If shown to be effective, these drugs may be extremely important in the current clinical practice.KEYWORDS: Antibioticantibacterial resistancenatural antibacterialsynthetic antibacterialtechnological prospecting Article highlights Bacterial antibiotic resistance has been considered one of the main threats to public health and the global economy since it is a growing crisis in medicine.New solutions on pharmacotherapies for bacterial infections are a persistent need, including the identification of alternatives with better pharmacological profiles, more potent and safer, presenting fewer side effects.The inclusion complexes formed by cyclodextrins have been possibility to improve the physicochemical and pharmacological properties of the formulation molecules.The review was carried out without restriction on the publication date and the search was established until August 2022 in any language in the free and online database Espacenet.Antibiotics, already on the market, natural products, and synthesized molecules composed the formulation with cyclodextrin or its derivates, developing treatments for bacterial infections and improving the possibilities to wrestle against bacterial resistance.This box summarizes key points contained in the article.Declaration of interestThe authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.Reviewer disclosuresPeer reviewers on this manuscript have no relevant financial or other relationships to disclose.Additional informationFundingThis study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001.The authors thank CAPES and FAPITEC/SE for their financial support.