对映选择合成
对称化
合成子
化学
水解
有机化学
立体化学
催化作用
作者
Gao-feng Yang,Yuan Yuan,Tian Yin,Shiqi Zhang,Xin Cui,Bing Xia,Guangxun Li,Zhuo Tang
摘要
Direct construction of chiral S(VI) from prochiral S(II) is a formidable challenge due to the inevitable formation of stable chiral S(IV). Previous synthetic strategies rely on the conversion of chiral S(IV) or enantioselective desymmetrization of preformed symmetrical S(VI) substrates. Here, we report desymmetrizing enantioselective hydrolysis of in situ-generated symmetric aza-dichlorosulfonium from sulfenamides for the preparation of chiral sulfonimidoyl chlorides, which could be used as a general stable synthon for obtaining a series of chiral S(VI) derivatives.
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