生物
早产
转录组
免疫系统
生物信息学
蜕膜
细胞
单细胞分析
子宫
细胞生物学
基因
生物信息学
免疫学
遗传学
基因表达
怀孕
胎儿
胎盘
作者
Valeria Garcia‐Flores,Roberto Romero,Azam Peyvandipour,José Galaz,Errile Pusod,Bogdan Panaitescu,Derek Miller,Yi Xu,Tao Li,Zhenjie Liu,Adi L. Tarca,Roger Piqué-Regi,Nardhy Gómez-López
出处
期刊:Cell Reports
[Elsevier]
日期:2023-01-01
卷期号:42 (1): 111846-111846
被引量:10
标识
DOI:10.1016/j.celrep.2022.111846
摘要
Preterm birth, the leading cause of perinatal morbidity and mortality worldwide, frequently results from the syndrome of preterm labor. The best-established causal link to preterm labor is intra-amniotic infection, which involves premature activation of the parturition cascade in the reproductive tissues. Herein, we utilize single-cell RNA sequencing (scRNA-seq) to generate a single-cell atlas of the murine uterus, decidua, and cervix in a model of infection-induced preterm labor. We show that preterm labor affects the transcriptomic profiles of specific immune and non-immune cell subsets. Shared and tissue-specific gene expression signatures are identified among affected cells. Determination of intercellular communications implicates specific cell types in preterm labor-associated signaling pathways across tissues. In silico comparison of murine and human uterine cell-cell interactions reveals conserved signaling pathways implicated in labor. Thus, our scRNA-seq data provide insights into the preterm labor-driven cellular landscape and communications in reproductive tissues.
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