催化作用
纳米-
原位
细菌
材料科学
化学工程
粘附
抗菌活性
化学
纳米技术
有机化学
复合材料
生物
遗传学
工程类
作者
Zhihui Niu,Mingxiao Xie,Zicheng Wei,Yang Guo,Mengxuan Han,Yingying Ding,Jianyu Huang,Kang Zheng,Yao Zhang,Yuanda Song,Dechao Niu,Yongsheng Li,Guangwu Wen,Xiaowei Li,Jianlin Shi
标识
DOI:10.1002/adhm.202202441
摘要
Nano-catalytic bacterial killing provides new opportunities to address ever-increasing antibiotic resistance. However, the intrinsic catalytic activity usually depends on a much lower pH conditions (pH = 2-5) than that in the weakly acidic bacterial microenvironments (pH = 6-7) for reactive oxygen species production by Fenton reactions. Herein, a MnSiO3 -based pH-ultrasensitive "in situ structure transformation" is first reported to significantly promote the adhesion between material and bacteria, and shorten the diffusion distance (<20 nm) to compensate ultra-short life (<200 ns) of ·OH generated by Mn2+ -mediated Fenton-like reaction, finally enhancing its nano-catalytic antibacterial performance in weakly acidic conditions. A separated spray bottle is further designed to achieve in situ gelation at the wound site, which demonstrates excellent shape adaptability to complicated and rough surfaces of wounds, allowing for long-term nano-catalyst release. As a result, bacterial-infected wound healing is efficiently promoted. Herein, the in situ sprayed nano-catalytic antibacterial gel presents a promising paradigm for bacterial infection treatment.
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