Single-nucleus RNA sequencing reveals Cntnap2+ astrocytes triggering a hypertensive effect in the rostral ventrolateral medulla by disrupting glutamate uptake

Our findings suggest that Cntnap2 may impede glutamate homeostasis at least partially through regulating Eaat2 in astrocytes, which could consequently enhance RVLM neuronal excitability, increase sympathetic tone, and contribute to elevated BP.