即时
粘附
高分子科学
聚合物
化学
食品科学
有机化学
作者
Benjamin R. Freedman,Juan A. Cintron Cruz,Phoebe S. Kwon,Matthew Lee,Haley M. Jeffers,Daniel L. Kent,Kyle Wu,James C. Weaver,David J. Mooney
标识
DOI:10.1073/pnas.2304643121
摘要
Generating strong rapid adhesion between hydrogels has the potential to advance the capabilities of modern medicine and surgery. Current hydrogel adhesion technologies rely primarily on liquid-based diffusion mechanisms and the formation of covalent bonds, requiring prolonged time to generate adhesion. Here, we present a simple and versatile strategy using dry chitosan polymer films to generate instant adhesion between hydrogel–hydrogel and hydrogel–elastomer surfaces. Using this approach we can achieve extremely high adhesive energies (>3,000 J/m 2 ), which are governed by pH change and non-covalent interactions including H-bonding, Van der Waals forces, and bridging polymer entanglement. Potential examples of biomedical applications are presented, including local tissue cooling, vascular sealing, prevention of surgical adhesions, and prevention of hydrogel dehydration. We expect these findings and the simplicity of this approach to have broad implications for adhesion strategies and hydrogel design.
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