毛螺菌科
肠道菌群
结肠炎
脂质代谢
溃疡性结肠炎
内分泌学
免疫学
内科学
高脂血症
药理学
医学
生物
生物化学
糖尿病
基因
厚壁菌
疾病
16S核糖体RNA
作者
Youbao Zhong,Qiuping Xiao,Jiaqi Huang,S Y Yu,Liling Chen,Qi Wan,Z. Zhang,Li‐Rong Lin,Lijun Song,Hai-Mei Zhao,Wen Zhou,Duan-Yong Liu
标识
DOI:10.1021/acs.jafc.3c04811
摘要
Ginsenoside Rg1 (G-Rg1) has various pharmacological properties including antiobesity, immunomodulatory, and anti-inflammatory effects. This study aimed to explore the therapeutic effects and underlying mechanisms of G-Rg1 on colitis complicated by obesity. The results indicate that G-Rg1 effectively alleviates colitis in obese mice and improves serum lipid levels and liver function. Importantly, G-Rg1 improved the composition of gut microbiota in obese mice with colitis, with increases in alpha diversity indexes Sobs, Ace, and Chao, a significant down-regulation of the relative abundance of Romboutsia, and a significant up-regulation of Rikenellaceae_RC9_gut_group, Lachnospiraceae_NK4A136_group, Enterorhabdus, Desulfovibrio, and Alistipes. Meanwhile, G-Rg1 improved lipid metabolism in the colonic contents of obese mice with colitis. Additionally, G-Rg1 significantly reduced the percentages of helper T (Th)1, Th17, central memory T (TCM), and effector memory T (TEM) cells in obese mice with colitis while significantly increasing Naïve T and Th2 cells. In conclusion, G-Rg1 could be a promising therapeutic option for alleviating obesity complicated by colitis through regulation of the gut microbiota and lipid metabolism as well as Th1/Th2/Th17 cell differentiation.
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