高海拔对人类的影响
网织红细胞
缺氧(环境)
血红蛋白
高度(三角形)
内科学
内分泌学
医学
生理学
化学
生物
氧气
生物化学
解剖
基因
信使核糖核酸
有机化学
数学
几何学
作者
Muge Qile,Qiying Xu,Yi Ye,Huifang Liu,Drolma Gomchok,Juanli Liu,Tana Wuren,Ri‐Li Ge
出处
期刊:High Altitude Medicine & Biology
[Mary Ann Liebert]
日期:2023-06-01
卷期号:24 (2): 104-109
被引量:2
标识
DOI:10.1089/ham.2022.0151
摘要
Qile, Muge, Qiying Xu, Yi Ye, Huifang Liu, Drolma Gomchok, Juanli Liu, Tana Wuren, and Ri-Li Ge. Erythrocytes display metabolic changes in high-altitude polycythemia. High Alt Med Biol. 24:104-109, 2023. Background: Sphingosine-1-phosphate (S1P) levels are increased after acute exposure to high altitude; however, whether this effect is observed in chronic high-altitude hypoxia is unknown. Methods: We studied erythrocyte S1P levels in 13 subjects with high-altitude polycythemia (HAPC) and 13 control subjects and also used a mouse model of HAPC. HAPC subjects lived in Maduo (4,300 m altitude) for 10 years, whereas control subjects lived permanently in Xining (2,260 m). The mouse model of HAPC was established by stimulating an altitude of 5,000 m in a hypobaric chamber for 30 days. Hematology and S1P, CD73, 2,3-bisphosphoglycerate (2,3-BPG), and reticulocyte levels were measured. Results: The hemoglobin concentration and number of red blood cells were significantly elevated in human and mouse HAPC groups. Blood S1P levels in HAPC subjects and mice were higher than those in control groups (p < 0.05 and p < 0.001, respectively). 2,3-BPG and CD73 levels in HAPC subjects were significantly higher than those in control subjects (p < 0.05). No significant changes in reticulocyte levels were observed. Conclusions: The critical altitude-induced metabolic changes such as S1P retained high levels even after prolonged exposure, and it may inspire future research into therapeutic strategies for hypoxia-associated illnesses.
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