高价分子
甲酰胺类
化学
催化作用
废止
钴
碘
路易斯酸
功能群
组合化学
有机化学
药物化学
聚合物
作者
Lipeng Long,Xin Li,Yu Wang,Xing Su,Liang Qiao,Wenjun Luo,Zhengwang Chen
标识
DOI:10.1021/acs.joc.3c00547
摘要
Herein, we disclose a practical and simple procedure to synthesize 2-aminobenzoxaoles. Simple anilines and formamides were used as substrates. The C–H bond ortho to the amino group in the anilines was directly functionalized under cobalt-catalyzed conditions with high levels of functional group tolerance. Hypervalent iodine(III) was both an oxidant and a Lewis acid for this reaction. The mechanism study showed that this transformation may involve a radical process.
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