Electrodynamic therapy: Novel nanodynamic strategy for anticancer and anti-infection therapy

Nanodynamic therapy (NDT) as an effective candidate strategy has made great achievements in the treatment of tumors, bacterial infections and other related diseases. However, the in vivo therapeutic effect of traditional NDT is heavily dependent on the tissue microenvironment, but which is often hypoxic and absence of H2O2. Therefore, a new strategy that is insensitive to the concentration of oxygen and H2O2 in the tissue microenvironment is necessary. Electrodynamic therapy (EDT) is a new type of NDT that generates reactive oxygen species by dissociating water under alternating current introduction, which is considered as a promising solution strategy. This tutorial review is firstly intended to provide an introduction of the current advances in EDT for anticancer and anti-infection therapy, which covers topics from the electrosensitizer classified by the types of platforms, to the EDT-based therapy including mono- and bimodal synergistic therapy, as well as the researches of the treatment applications (anticancer applications and bacterial infection) are also discussed. Finally, the current status and future prospects of EDT are summarized. We hope that this timely and comprehensive review will shed light on the value and future prospects of EDT, and that further research is needed to achieve its further development.