分子成像
正电子发射断层摄影术
小分子
化学
跨膜蛋白
癌症研究
医学
核医学
生物化学
体内
生物
生物技术
受体
作者
Chengxue He,Futao Liu,Jinping Tao,Zilei Wang,Jiayue Liu,Song Liu,Xiaoxia Xu,Liqiang Li,Feng Wang,Xianteng Yang,Hua Zhu,Zhi Yang
标识
DOI：10.1021/acs.molpharmaceut.4c00104
摘要
Carbonic anhydrase IX (CAIX), a zinc metal transmembrane protein, is highly expressed in 95% of clear cell renal cell carcinomas (ccRCCs). A positron emission tomography (PET) probe designed to target CAIX in nuclear medicine imaging technology can achieve precise positioning, is noninvasive, and can be used to monitor CAIX expression in lesions in real time. In this study, we constructed a novel acetazolamide dual-targeted small-molecule probe [
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