医学
超重
糖尿病
2型糖尿病
肥胖
认知功能衰退
内科学
痴呆
观察研究
老年学
物理疗法
疾病
内分泌学
作者
Michelle M. Mielke,Joni K. Evans,Rebecca H. Neiberg,Doris Molina-Henry,Santica M. Marcovina,Karen Johnson,Owen Carmichael,Stephen R. Rapp,Bonnie C. Sachs,Jingzhong Ding,Heather M. Shappell,José A. Luchsinger,Mark A. Espeland,Kathleen M. Hayden
出处
期刊：JAMA network open
[American Medical Association]
日期：2025-02-06
卷期号：8 (2): e2458149-e2458149
被引量：13
标识
DOI：10.1001/jamanetworkopen.2024.58149
摘要
In this study of participants with T2D and overweight or obesity, increasing plasma NfL and GFAP levels over time, but not Aβ42/40 or pTau-181 levels, were associated with cognitive decline and incident cognitive impairment. These results suggest that plasma NfL and GFAP may be important biomarkers of cognitive change among this patient population.
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