Silver‐mediated in‐situ generation of alkynyl selenium intramolecular AAC click reactions

A simple and efficient Ag‐catalyzed tandem selanylation/cyclization of o‐alkynyl benzylazides/o‐alkynyloxy benzylazides with diselenides has been developed. The reaction afforded a series of 3‐seleno‐8H‐[1,2,3]triazolo[5,1‐a]isoindoles and 3‐seleno‐4H,10H‐benzo[f][1,2,3]triazolo[5,1‐c][1,4]oxazepanes in moderate to good yields. The mechanistic study revealed that the intramolecular AAC reaction of an alkynyl selenium intermediate occurred. The synthesized compound 3k showed potent cancer cell‐growth inhibition activities.