奇纳
结果(博弈论)
医学
梅德林
系统回顾
观察研究
荟萃分析
临床试验
口腔医学
牙科
病理
心理干预
数学
数理经济学
法学
精神科
政治学
作者
Paswach Wiriyakijja,Sven Niklander,Alan Roger Santos‐Silva,Michal Kuten Shorrer,Melanie Simms,Alessandro Villa,Vidya Sankar,Alexander Ross Kerr,Richeal Ní Ríordáin,Siri Beier Jensen,Konstantina Delli
标识
DOI:10.1016/j.oooo.2023.01.012
摘要
The purpose of this study was to identify all outcome domains used in clinical studies of xerostomia, that is, subjective sensation of dry mouth. This study is part of the extended project "World Workshop on Oral Medicine Outcomes Initiative for the Direction of Research" to develop a core outcome set for dry mouth.A systematic review was performed on MEDLINE, EMBASE, CINAHL, and Cochrane Central Register of Controlled Trials databases. All clinical and observational studies that assessed xerostomia in human participants from 2001 to 2021 were included. Information on outcome domains was extracted and mapped to the Core Outcome Measures in Effectiveness Trials taxonomy. Corresponding outcome measures were summarized.From a total of 34,922 records retrieved, 688 articles involving 122,151 persons with xerostomia were included. There were 16 unique outcome domains and 166 outcome measures extracted. None of these domains or measures were consistently used across all the studies. The severity of xerostomia and physical functioning were the 2 most frequently assessed domains.There is considerable heterogeneity in outcome domains and measures reported in clinical studies of xerostomia. This highlights the need for harmonization of dry mouth assessment to enhance comparability across studies and facilitate the synthesis of robust evidence for managing patients with xerostomia.
科研通智能强力驱动
Strongly Powered by AbleSci AI