眼睑炎
医学
睑板腺
抗生素
阿奇霉素
皮肤病科
蠕形螨
强力霉素
不利影响
疾病
重症监护医学
眼睑
外科
内科学
螨
微生物学
生物
植物
作者
Ragnheidur R. Vernhardsdottir,Morten Schjerven Magno,Leif Hynnekleiv,Neil Lagali,Darlene A. Dartt,Jelle Vehof,Catherine Jackson,Tor Paaske Utheim
标识
DOI:10.1016/j.jtos.2022.08.010
摘要
Dry eye disease (DED) is among the most prevalent ophthalmic conditions but is often underdiagnosed and mistreated. Antibiotics are regularly used to treat DED caused by meibomian gland dysfunction (MGD) or blepharitis, but their use has been questioned. To critically evaluate the use of oral and topical antibiotics in DED management. A literature search was conducted on November 15th, 2021, in the PubMed database. The search terms were: (antibiotics OR azithromycin OR doxycycline OR minocycline) AND (dry eye disease OR meibomian gland OR blepharitis anterior OR blepharitis posterior OR chronic blepharitis). All relevant original articles with English full-text were included. Case reports and review articles were excluded. The search provided 619 articles, of which 22 met the inclusion criteria. Oral and topical antibiotics appeared to have short-term positive effects on signs and symptoms of blepharitis- or MGD-related DED. However, these improvements often reverted upon cessation of treatment. The need for repeated treatments and mild adverse events were common. Current evidence suggests that patients with blepharitis- or MGD-related DED experience short-term benefits of antibiotics. However, evidence for lasting improvement after completed treatment was lacking. Given the unclear long-term benefits, common side effects, and increasing antibiotic resistance seen globally, the existing literature is not sufficient to conclude that antibiotics are useful in long-term MGD management. A survival-analysis of a single round of antibiotics, in addition to the effects of repeated rounds of treatment, on DED parameters could provide useful insights.
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